The default mode network and self-referential processes in depression
نویسندگان
چکیده
منابع مشابه
The default mode network and self-referential processes in depression.
The recently discovered default mode network (DMN) is a group of areas in the human brain characterized, collectively, by functions of a self-referential nature. In normal individuals, activity in the DMN is reduced during nonself-referential goal-directed tasks, in keeping with the folk-psychological notion of losing one's self in one's work. Imaging and anatomical studies in major depression ...
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Investigation of the neural correlates of the self has implicated a network of brain regions including the medial prefrontal cortex (MPFC), posterior cingulate (PCC), precuneus (pC), and inferior parietal lobule (IPL). At the same time, recent neuroimaging work has identified the Default Mode Network (DMN), a network of brain regions that are highly active at ‘rest’ (without an active cognitive...
متن کاملDefault-mode network dysfunction and self-referential processing in healthy siblings of schizophrenia patients
The default-mode network (DMN) of the brain shows highly coherent intrinsic activity in healthy subjects and is implicated in self-referential processing important for social cognitive functioning. Schizophrenia patients show abnormal resting-state connectivity within the DMN and this aberrant connectivity is thought to contribute to difficulties in self-referential and introspective processing...
متن کاملReduced negative BOLD responses in the default-mode network and increased self-focus in depression.
OBJECTIVES Functional imaging studies in major depressive disorder (MDD) indicate abnormal resting state neural activity and negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network (DMN). METHODS Since activity in DMN regions has been associated with self-relatedness, we investigated neural activity in these regions during self-related emotion...
متن کاملMapping the self in the brain's default mode network
The brain's default mode network (DMN) has become closely associated with self-referential mental activity, particularly in the resting-state. While the DMN is important for such processes, it has functions other than self-reference, and self-referential processes are supported by regions outside of the DMN. In our study of 88 participants, we examined self-referential and resting-state process...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0812686106